edoc

Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study

Usemann, Jakob and Suter, Andrea and Zannin, Emanuela and Proietti, Elena and Fouzas, Sotirios and Schulzke, Sven and Latzin, Philipp and Frey, Urs and Bild study group, . (2019) Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study. Journal of Pediatrics, 205. pp. 61-69.e1.

[img] PDF - Published Version
Restricted to Repository staff only

1061Kb

Official URL: https://edoc.unibas.ch/82168/

Downloads: Statistics Overview

Abstract

To test whether low variability of tidal volume (V; T; ) and capnographic indices are predictive of subsequent respiratory morbidity in preterm infants.; In a birth cohort of 133 preterm infants, lung function was performed at 44 weeks postmenstrual age. Associations between the coefficient of variation (CV) of V; T; (CV; VT; ) and of expired CO; 2; volume per breath (CV; VE,CO2; ) with rehospitalization, wheeze, and inhalation therapy during infancy were assessed using logistic regression. Area under the curve (AUC) analysis was used to assess whether outcome prediction using bronchopulmonary dysplasia (BPD) classification was enhanced by CV; VT; or CV; VE,CO2; .; For each IQR decrease in CV; VT; (range, 4%-35%) and CV; VE; ,; CO2; (range, 5%-40%), the OR for rehospitalization increased by 2.25 (95% CI, 1.21-4.20) and 2.31 (95% CI, 1.20-4.45), respectively. The predictive value of BPD for rehospitalization was improved when CV; VT; or CV; VE,CO2; was added to the model, with the AUC increasing from 0.56 to 0.66 in both models. No association was found for the other outcomes.; Compared with BPD classification alone, including near-term variability of tidal breathing parameters improves the prediction of rehospitalization in infancy. These findings may inform parent counseling and monitoring strategies in preterm infants.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
UniBasel Contributors:Schulzke, Sven and Usemann, Jakob and Frey, Urs Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0022-3476
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:11 Jul 2022 12:58
Deposited On:03 Mar 2021 14:30

Repository Staff Only: item control page