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Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma

Roberts, Graham and Fontanella, Sara and Selby, Anna and Howard, Rebecca and Filippi, Sarah and Hedlin, Gunilla and Nordlund, Bjorn and Howarth, Peter and Hashimoto, Simone and Brinkman, Peter and Fleming, Louise J. and Murray, Clare and Bush, Andrew and Frey, Urs and Singer, Florian and Schoos, Ann-Marie Malby and van Aalderen, Wim and Djukanovic, Ratko and Chung, K. Fan and Sterk, Peter J. and Adnan, Custovic and U-Biopred Consortium, . (2020) Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma. The Journal of Allergy & Clinical Immunology, 146 (4). pp. 821-830.

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Abstract

Allergic sensitization is associated with severe asthma, but assessment of sensitization is not recommended by most guidelines.; We hypothesized that patterns of IgE responses to multiple allergenic proteins differ between sensitized participants with mild/moderate and severe asthma.; IgE to 112 allergenic molecules (components, c-sIgE) was measured using multiplex array among 509 adults and 140 school-age and 131 preschool children with asthma/wheeze from the Unbiased BIOmarkers for the PREDiction of respiratory diseases outcomes cohort, of whom 595 had severe disease. We applied clustering methods to identify co-occurrence patterns of components (component clusters) and patterns of sensitization among participants (sensitization clusters). Network analysis techniques explored the connectivity structure of c-sIgE, and differential network analysis looked for differences in c-sIgE interactions between severe and mild/moderate asthma.; Four sensitization clusters were identified, but with no difference between disease severity groups. Similarly, component clusters were not associated with asthma severity. None of the c-sIgE were identified as associates of severe asthma. The key difference between school children and adults with mild/moderate compared with those with severe asthma was in the network of connections between c-sIgE. Participants with severe asthma had higher connectivity among components, but these connections were weaker. The mild/moderate network had fewer connections, but the connections were stronger. Connectivity between components with no structural homology tended to co-occur among participants with severe asthma. Results were independent from the different sample sizes of mild/moderate and severe groups.; The patterns of interactions between IgE to multiple allergenic proteins are predictors of asthma severity among school children and adults with allergic asthma.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
UniBasel Contributors:Frey, Urs Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0091-6749
e-ISSN:1097-6825
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
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Last Modified:12 Apr 2021 09:50
Deposited On:03 Mar 2021 14:24

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