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eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy

Abdel-Aziz, Mahmoud I. and Brinkman, Paul and Vijverberg, Susanne J. H. and Neerincx, Anne H. and de Vries, Rianne and Dagelet, Yennece W. F. and Riley, John H. and Hashimoto, Simone and Montuschi, Paolo and Chung, Kian Fan and Djukanovic, Ratko and Fleming, Louise J. and Murray, Clare S. and Frey, Urs and Bush, Andrew and Singer, Florian and Hedlin, Gunilla and Roberts, Graham and Dahlén, Sven-Erik and Adcock, Ian M. and Fowler, Stephen J. and Knipping, Karen and Sterk, Peter J. and Kraneveld, Aletta D. and Maitland-van der Zee, Anke H. and U-Biopred Study Group, and Amsterdam UMC Breath Research Group, . (2020) eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy. Journal of Allergy and Clinical Immunology, 146 (5). pp. 1045-1055.

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Abstract

Electronic noses (eNoses) are emerging point-of-care tools that may help in the subphenotyping of chronic respiratory diseases such as asthma.; We aimed to investigate whether eNoses can classify atopy in pediatric and adult patients with asthma.; Participants with asthma and/or wheezing from 4 independent cohorts were included; BreathCloud participants (n = 429), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes adults (n = 96), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes pediatric participants (n = 100), and Pharmacogenetics of Asthma Medication in Children: Medication with Anti-Inflammatory Effects 2 participants (n = 30). Atopy was defined as a positive skin prick test result (≥3 mm) and/or a positive specific IgE level (≥0.35 kU/L) for common allergens. Exhaled breath profiles were measured by using either an integrated eNose platform or the SpiroNose. Data were divided into 2 training and 2 validation sets according to the technology used. Supervised data analysis involved the use of 3 different machine learning algorithms to classify patients with atopic versus nonatopic asthma with reporting of areas under the receiver operating characteristic curves as a measure of model performance. In addition, an unsupervised approach was performed by using a bayesian network to reveal data-driven relationships between eNose volatile organic compound profiles and asthma characteristics.; Breath profiles of 655 participants (n = 601 adults and school-aged children with asthma and 54 preschool children with wheezing [68.2% of whom were atopic]) were included in this study. Machine learning models utilizing volatile organic compound profiles discriminated between atopic and nonatopic participants with areas under the receiver operating characteristic curves of at least 0.84 and 0.72 in the training and validation sets, respectively. The unsupervised approach revealed that breath profiles classifying atopy are not confounded by other patient characteristics.; eNoses accurately detect atopy in individuals with asthma and wheezing in cohorts with different age groups and could be used in asthma phenotyping.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
UniBasel Contributors:Frey, Urs Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0091-6749
e-ISSN:1097-6825
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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edoc DOI:
Last Modified:03 Mar 2021 08:30
Deposited On:02 Mar 2021 14:51

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