Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Wan, Chenjie and Bachmann, Nadine and Mitov, Venelin and Blanquart, François and Céspedes, Susana Posada and Turk, Teja and Neumann, Kathrin and Beerenwinkel, Niko and Bogojeska, Jasmina and Fellay, Jacques and Roth, Volker and Böni, Jürg and Perreau, Matthieu and Klimkait, Thomas and Yerly, Sabine and Battegay, Manuel and Walti, Laura and Calmy, Alexandra and Vernazza, Pietro and Bernasconi, Enos and Cavassini, Matthias and Metzner, Karin J. and Günthard, Huldrych F. and Kouyos, Roger D. and Swiss HIV Cohort Study, . (2020) Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART. Nature Communications, 11 (1). p. 5542.

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Official URL: https://edoc.unibas.ch/81732/

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The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on viral phylogenies from both partial-pol and viral near full-length genome sequences. We use a unique nationwide cohort of 610 well-characterized HIV-1 subtype-B infected individuals on suppressive ART for a median of 5.4 years. We find that a moderate but significant fraction of the HIV-1 reservoir size 1.5 years after the initiation of ART is explained by genetic factors. At the same time, we find more tentative evidence for the heritability of the long-term HIV-1 reservoir decay. Our findings indicate that viral genetic factors contribute to the HIV-1 reservoir size and hence the infecting HIV-1 strain may affect individual patients' hurdle towards a cure.
Faculties and Departments:05 Faculty of Science > Departement Mathematik und Informatik > Informatik > Datenanalyse (Roth)
UniBasel Contributors:Roth, Volker
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Apr 2021 12:50
Deposited On:12 Apr 2021 12:50

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