Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment

Thorball, Christian W. and Borghesi, Alessandro and Bachmann, Nadine and Von Siebenthal, Chantal and Vongrad, Valentina and Turk, Teja and Neumann, Kathrin and Beerenwinkel, Niko and Bogojeska, Jasmina and Roth, Volker and Kok, Yik Lim and Parbhoo, Sonali and Wieser, Mario and Böni, Jürg and Perreau, Matthieu and Klimkait, Thomas and Yerly, Sabine and Battegay, Manuel and Rauch, Andri and Schmid, Patrick and Bernasconi, Enos and Cavassini, Matthias and Kouyos, Roger D. and Günthard, Huldrych F. and Metzner, Karin J. and Fellay, Jacques and Swiss HIV Cohort Study, . (2020) Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment. Journal of Acquired Immune Deficiency Syndromes, 85 (4). pp. 517-524.

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Official URL: https://edoc.unibas.ch/81731/

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The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here, we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatment.; Genome-wide association study and exome sequencing study to look for host genetic determinants of HIV-1 reservoir measurements in patients enrolled in the Swiss HIV Cohort Study, a nation-wide prospective observational study.; We measured total HIV-1 DNA in peripheral blood mononuclear cells from study participants, as a proxy for the reservoir size at 3 time points over a median of 5.4 years, and searched for associations between human genetic variation and 2 phenotypic readouts: the reservoir size at the first time point and its decay rate over the study period. We assessed the contribution of common genetic variants using genome-wide genotyping data from 797 patients with European ancestry enrolled in the Swiss HIV Cohort Study and searched for a potential impact of rare variants and exonic copy number variants using exome sequencing data generated in a subset of 194 study participants.; Genome-wide and exome-wide analyses did not reveal any significant association with the size of the HIV-1 reservoir or its decay rate on suppressive antiretroviral treatment.; Our results point to a limited influence of human genetics on the size of the HIV-1 reservoir and its long-term dynamics in successfully treated individuals.
Faculties and Departments:05 Faculty of Science > Departement Mathematik und Informatik > Informatik > Biomedical Data Analysis (Roth)
UniBasel Contributors:Roth, Volker and Parbhoo, Sonali and Wieser, Mario
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott, Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Apr 2021 12:40
Deposited On:12 Apr 2021 12:40

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