Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis

Fregni, Giulia and Quinodoz, Mathieu and Möller, Emely and Vuille, Joanna and Galland, Sabine and Fusco, Carlo and Martin, Patricia and Letovanec, Igor and Provero, Paolo and Rivolta, Carlo and Riggi, Nicolo and Stamenkovic, Ivan. (2018) Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis. EBioMedicine, 29. pp. 128-145.

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Official URL: https://edoc.unibas.ch/81696/

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Metastasis is a multi-step process in which direct crosstalk between cancer cells and their microenvironment plays a key role. Here, we assessed the effect of paired tumor-associated and normal lung tissue mesenchymal stem cells (MSCs) on the growth and dissemination of primary human lung carcinoma cells isolated from the same patients. We show that the tumor microenvironment modulates MSC gene expression and identify a four-gene MSC signature that is functionally implicated in promoting metastasis. We also demonstrate that tumor-associated MSCs induce the expression of genes associated with an aggressive phenotype in primary lung cancer cells and selectively promote their dissemination rather than local growth. Our observations provide insight into mechanisms by which the stroma promotes lung cancer metastasis.
Faculties and Departments:03 Faculty of Medicine
09 Associated Institutions > Institute of Molecular and Clinical Ophthalmology Basel (IOB)
UniBasel Contributors:Rivolta, Carlo
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 Feb 2021 15:07
Deposited On:26 Feb 2021 15:07

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