ProMod3-A versatile homology modelling toolbox

Studer, Gabriel and Tauriello, Gerardo and Bienert, Stefan and Biasini, Marco and Johner, Niklaus and Schwede, Torsten. (2021) ProMod3-A versatile homology modelling toolbox. PLoS Computational Biology, 17 (1). e1008667.

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Official URL: https://edoc.unibas.ch/81614/

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Computational methods for protein structure modelling are routinely used to complement experimental structure determination, thus they help to address a broad spectrum of scientific questions in biomedical research. The most accurate methods today are based on homology modelling, i.e. detecting a homologue to the desired target sequence that can be used as a template for modelling. Here we present a versatile open source homology modelling toolbox as foundation for flexible and computationally efficient modelling workflows. ProMod3 is a fully scriptable software platform that can perform all steps required to generate a protein model by homology. Its modular design aims at fast prototyping of novel algorithms and implementing flexible modelling pipelines. Common modelling tasks, such as loop modelling, sidechain modelling or generating a full protein model by homology, are provided as production ready pipelines, forming the starting point for own developments and enhancements. ProMod3 is the central software component of the widely used SWISS-MODEL web-server.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede)
UniBasel Contributors:Schwede, Torsten and Studer, Gabriel and Tauriello, Gerardo and Bienert, Stefan and Biasini, Marco and Johner, Niklaus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Library of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2021 11:59
Deposited On:31 Aug 2021 11:59

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