Symptoms and quality of life in patients with coexistent atrial fibrillation and atrial flutter

Stempfel, Samuel and Aeschbacher, Stefanie and Blum, Steffen and Meyre, Pascal and Gugganig, Rebecca and Beer, Jürg H. and Kobza, Richard and Kühne, Michael and Moschovitis, Giorgio and Menghini, Gianluca and Novak, Jan and Osswald, Stefan and Rodondi, Nicolas and Moutzouri, Elisavet and Schwenkglenks, Matthias and Witassek, Fabienne and Conen, David and Sticherling, Christian and Swiss-AF study investigators, . (2020) Symptoms and quality of life in patients with coexistent atrial fibrillation and atrial flutter. International journal of cardiology. Heart & vasculature, 29. p. 100556.

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Official URL: https://edoc.unibas.ch/81602/

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Atrial fibrillation (AF) and atrial flutter (AFL) are two of the most common atrial arrhythmias and often coexist. Many patients with AF or AFL are symptomatic, which impacts their quality of life (QoL). The purpose of this study was to determine whether coexistent AFL represents an added burden for AF patients.; We combined baseline data from two large prospective, observational, multicenter cohort studies (BEAT-AF and Swiss-AF). All 3931 patients included in this analysis had documented AF. We obtained information on comorbidities, medication, and lifestyle factors; .; All participants had a clinical examination and a resting ECG. Symptom burden and QoL at the baseline examination were compared between patients with and without coexistent AFL using multivariable adjusted regression models.; Overall, 809 (20.6%) patients had a history of AFL. Patients with coexistent AFL more often had history of heart failure (28% vs 23%, p = 0.01), coronary artery disease (30% vs 26%, p = 0.007), failed therapy with antiarrhythmic drugs (44% vs 29%, p < 0.001), and more often underwent AF-related interventions (36% vs 17%, p < 0.001). They were more often symptomatic (70% vs 66%, p = 0.04) and effort intolerant (OR: 1.14; 95% CI: 1.01-1.28; p = 0.04). Documented AFL on the baseline ECG was associated with more symptoms (OR: 2.30; 95% CI: 1.26-4.20; p = 0.007).; Our data indicates that patients with coexistent AF and AFL are more often symptomatic and report poorer quality of life compared to patients suffering from AF only.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Pharmazeutische Medizin ECPM > Pharmazeutische Medizin (Szucs)
UniBasel Contributors:Schwenkglenks, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Apr 2021 13:17
Deposited On:12 Apr 2021 13:17

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