Differential familial liability of panic disorder and agoraphobia

Nocon, A. and Wittchen, H.-U. and Beesdo, K. and Brueckl, T. and Hoefler, M. and Pfister, H. and Zimmermann, P. and Lieb, R.. (2008) Differential familial liability of panic disorder and agoraphobia. Depression and anxiety, Vol. 25, H. 5. pp. 422-434.

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Official URL: http://edoc.unibas.ch/dok/A5248827

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To examine the familial liability of panic disorder (PD) and agoraphobia (A G) in a community sample, namely the effect of parental PD and A G on the offspring`s risk to develop either or both conditions in adolescence or adulthood. A representative community sample of N = 3,021 adolescents and young adults aged 14-24 years at baseline was followed up over a period of 10 years in up to four waves. Family information was assessed by either direct interviews with at least one parent or by using subjects` family history information at either wave (N = 3,014). Diagnoses and selected symptoms were assessed in both, parents and subjects, by using a standardized diagnostic interview (DSM-IV M-CIDI) with its respective family history module. (1) Parental panic attacks (PA), PD, and A G were all shown to be associated with an increased risk of offspring to also develop PA, PD, and A G. (2) Associations of parental PD were present irrespective of parental AG, whereas parental AG without PD was not associated with an increased offspring risk. (3) Outcome risk was particularly elevated in offspring of parents with PD+AG. (4) Parental PD or A G was not associated with an earlier age of onset of any syndrome in the offspring. We confirmed and expanded previous results from clinical samples that comorbid PD and AG aggregate in families. AG without PD is not familial, but it might enhance the familial transmission of PD.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Lieb, Roselind
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:42

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