Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus

Renzi, Francesco and Ittig, Simon J. and Sadovskaya, Irina and Hess, Estelle and Lauber, Frederic and Dol, Melanie and Shin, Hwain and Mally, Manuela and Fiechter, Chantal and Sauder, Ursula and Chami, Mohamed and Cornelis, Guy R.. (2016) Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus. Scientific Reports, 6. p. 38914.

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Capnocytophaga canimorsus is a dog's and cat's oral commensal which can cause fatal human infections upon bites or scratches. Infections mainly start with flu-like symptoms but can rapidly evolve in fatal septicaemia with a mortality as high as 40%. Here we present the discovery of a polysaccharide capsule (CPS) at the surface of C. canimorsus 5 (Cc5), a strain isolated from a fulminant septicaemia. We provide genetic and chemical data showing that this capsule is related to the lipooligosaccharide (LOS) and probably composed of the same polysaccharide units. A CPS was also found in nine out of nine other strains of C. canimorsus. In addition, the genomes of three of these strains, sequenced previously, contain genes similar to those encoding CPS biosynthesis in Cc5. Thus, the presence of a CPS is likely to be a common property of C. canimorsus. The CPS and not the LOS confers protection against the bactericidal effect of human serum and phagocytosis by macrophages. An antiserum raised against the capsule increased the killing of C. canimorsus by human serum thus showing that anti-capsule antibodies have a protective role. These findings provide a new major element in the understanding of the pathogenesis of C. canimorsus.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > BioEM Lab (Chami)
UniBasel Contributors:Chami, Mohamed
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Apr 2021 09:28
Deposited On:13 Apr 2021 09:28

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