Role of Retrosplenial cortex in flexible learning

In this thesis, I investigate the role of Retrosplenial cortex (RSC) in learning and uncover its previously unknown contribution to behavioural flexibility. Using chemogenetic tools in combination with viral tracing techniques, neuronal tagging methods and diverse behavioural tasks, I show how learning and updating affect RSC in terms of neuronal plasticity and memory allocation, and what the specific impairments caused by learning without RSC are. Finally, l investigate the role of the connections between RSC, the thalamus and the basal ganglia system in the implementation of its function.