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Role of Retrosplenial cortex in flexible learning

Serrano, Melissa. Role of Retrosplenial cortex in flexible learning. 2021, Doctoral Thesis, University of Basel, Faculty of Science.

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Abstract

In this thesis, I investigate the role of Retrosplenial cortex (RSC) in learning and uncover its previously unknown contribution to behavioural flexibility. Using chemogenetic tools in combination with viral tracing techniques, neuronal tagging methods and diverse behavioural tasks, I show how learning and updating affect RSC in terms of neuronal plasticity and memory allocation, and what the specific impairments caused by learning without RSC are. Finally, l investigate the role of the connections between RSC, the thalamus and the basal ganglia system in the implementation of its function.
Advisors:Caroni, Pico
Committee Members:Arber, Silvia
Faculties and Departments:09 Associated Institutions > Friedrich Miescher Institut FMI > Neurobiology > Plasticity of neuronal connections (Caroni)
UniBasel Contributors:Arber, Silvia
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:14037
Thesis status:Complete
Number of Pages:90
Language:English
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss140377
edoc DOI:
Last Modified:10 May 2021 11:34
Deposited On:22 Apr 2021 08:08

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