The catalytic mechanism of sulfoxide synthases

Stampfli, Anja R. and Seebeck, Florian P.. (2020) The catalytic mechanism of sulfoxide synthases. Current Opinion in Chemical Biology, 59. pp. 111-118.

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Official URL: https://edoc.unibas.ch/81366/

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Sulfoxide synthases are non-heme iron enzymes that catalyze oxidative carbonsulfur bond formation in the biosynthesis of thiohistidines such as ergothioneine and ovothiol. The catalytic mechanism of these enzymes has been studied by protein crystallography, steady-state kinetics, non-natural amino acid incorporation and computational modeling. This review discusses the current status of this research and also highlights similarities between the CS bond forming activity of sulfoxide synthases with that of synthetic coordination compounds.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Organische Chemie (Gademann)
UniBasel Contributors:Seebeck, Florian Peter and Stampfli, Anja
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2021 08:50
Deposited On:31 Jan 2021 17:27

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