Convergent Evolution of Fungal Cysteine Dioxygenases

Flückger, Sebastian and Igareta, Nico V. and Seebeck, Florian P.. (2020) Convergent Evolution of Fungal Cysteine Dioxygenases. ChemBioChem, 21 (21). pp. 3082-3086.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/81364/

Downloads: Statistics Overview


Cupin-type cysteine dioxygenases (CDOs) are non-heme iron enzymes that occur in animals, plants, bacteria and in filamentous fungi. In this report, we show that agaricomycetes contain an entirely unrelated type of CDO that emerged by convergent evolution from enzymes involved in the biosynthesis of ergothioneine. The activity of this CDO type is dependent on the ergothioneine precursor N-α-trimethylhistidine. The metabolic link between ergothioneine production and cysteine oxidation suggests that the two processes might be part of the same chemical response in fungi, for example against oxidative stress.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Organische Chemie (Gademann)
UniBasel Contributors:Seebeck, Florian Peter and Igareta, Nico Valerio
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Feb 2021 08:52
Deposited On:31 Jan 2021 17:31

Repository Staff Only: item control page