Sensitivity to intranasal oxytocin in adult men with early parental separation

Meinlschmidt, G. and Heim, C.. (2007) Sensitivity to intranasal oxytocin in adult men with early parental separation. Biological psychiatry, Vol. 61, H. 9. pp. 1109-1111.

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Official URL: http://edoc.unibas.ch/dok/A5254989

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BACKGROUND: Central oxytocin (OT) is critically involved in mediating social bonding and protecting against stress, depression, and anxiety. In animal models, early social experiences induce changes in central OT systems. In humans, early parental separation (EPS) increases the risk for emotional disorders in adulthood. We examined neuroendocrine responses to intranasal OT administration in men with EPS and healthy control subjects as an estimate of central OT sensitivity. METHODS: Salivary cortisol concentrations were measured in 9 healthy men with EPS and 10 control subjects before and after double-blind intranasal administration of placebo and OT (24 IU Syntocinon). RESULTS: Relative to placebo, intranasal OT resulted in attenuated cortisol decreases in EPS subjects compared with control subjects. CONCLUSIONS: These preliminary results may suggest altered central sensitivity to the effects of OT after EPS. Future studies should replicate these results and scrutinize the role of OT in mediating risk versus resilience to psychopathology after early social adversity.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Meinlschmidt, Gunther
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:42

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