Compartment-specific plasticity in the lateral amygdala during fear learning

d'Aquin, Simon. Compartment-specific plasticity in the lateral amygdala during fear learning. 2021, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

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Official URL: https://edoc.unibas.ch/81336/

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Local dendritic integration of synaptic inputs crucially shapes somatic output. While work in vitro has provided valuable insights into the mechanisms underlying dendritic integration, how experience affects the relationship between behaviorally relevant somatic and dendritic activity in single neurons remains largely unknown. Using deep brain two-photon Ca2+ imaging, we investigate how sensory stimuli are represented in somata and dendrites of Lateral Amygdala principal neurons and how these representations develop over the course of auditory fear learning. We observe a higher rate of dendrite-specific activity during tone presentations in naïve animals, which was abolished by chemogenetic inhibition of somatostatin-expressing interneurons, suggesting that these neurons gate dendritic integration of tone inputs. We also find that fear learning induces tone response plasticity that is bidirectional in somata but largely unidirectional in dendrites and identified a neuronal population with uncoupled somatic and dendritic plasticity of tone response. Overall, our results indicate that fear learning induces compartment-specific plasticity and suggests that inputs conveying tone information are processed locally in the amygdala during auditory fear learning.
Advisors:Lüthi, Andreas
Committee Members:Branco, Tiago
Faculties and Departments:09 Associated Institutions > Friedrich Miescher Institut FMI > Neurobiology > Cellular mechanisms of learning and memory (Lüthi)
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:14044
Thesis status:Complete
Number of Pages:72
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss140444
edoc DOI:
Last Modified:10 May 2021 13:45
Deposited On:10 May 2021 13:45

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