Catalytic Cascade Reactions Inspired by Polyketide Biosynthesis

Moser, Daniel and Castrogiovanni, Alessandro and Lotter, Dominik and Witzig, Reto M. and Fäseke, Vincent C. and Raps, Felix C. and Sparr, Christof. (2020) Catalytic Cascade Reactions Inspired by Polyketide Biosynthesis. Chimia, 74 (9). pp. 699-703.

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Aldol reactions belong to the most important methods for carbon-carbon bond formation and are also involved in one of the most astonishing biosynthetic processes: the biosynthesis of polyketides governed by an extraordinarily sophisticated enzymatic machinery. In contrast to the typical linear or convergent strategies followed in chemical synthesis, this late-stage catalysis concept allows Nature to assemble intermediates that are diversified into a broad range of scaffolds, which assume various crucial biological functions. To transfer this concept to small-molecule catalysis to access products beyond the natural systems, a stepwise approach to differentiate increasingly complex substrates was followed by investigating arene-forming polyketide cyclizations. An outline of our efforts to develop and apply these concepts are presented herein.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Sparr)
UniBasel Contributors:Sparr, Christof
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Schweizerische Chemische Gesellschaft
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Feb 2021 10:56
Deposited On:01 Feb 2021 12:20

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