edoc

Wnt Secretion Is Required to Maintain High Levels of Wnt Activity in Colon Cancer Cells

Voloshanenko, Oksana and Erdmann, Gerrit and Dubash, Taronish D. and Augustin, Iris and Metzig, Marie and Moffa, Giusi and Hundsrucker, Christian and Kerr, Grainne and Sandmann, Thomas and Anchang, Benedikt and Demir, Kubilay and Boehm, Christina and Leible, Svenja and Ball, Claudia R. and Glimm, Hanno and Spang, Rainer and Boutros, Michael. (2013) Wnt Secretion Is Required to Maintain High Levels of Wnt Activity in Colon Cancer Cells. Nature Communications, 4. p. 2610.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/81043/

Downloads: Statistics Overview

Abstract

Aberrant regulation of the Wnt/β-catenin pathway has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or β-catenin. However, it has remained a point of controversy whether these mutations are sufficient to activate the pathway or require additional upstream signals. Here we show that colorectal tumours express elevated levels of Wnt3 and Evi/Wls/GPR177. We found that in colon cancer cells, even in the presence of mutations in APC or β-catenin, downstream signalling remains responsive to Wnt ligands and receptor proximal signalling. Furthermore, we demonstrate that truncated APC proteins bind β-catenin and key components of the destruction complex. These results indicate that cells with mutations in APC or β-catenin depend on Wnt ligands and their secretion for a sufficient level of β-catenin signalling, which potentially opens new avenues for therapeutic interventions by targeting Wnt secretion via Evi/Wls.
Faculties and Departments:05 Faculty of Science > Departement Mathematik und Informatik > Mathematik > Statistik (Moffa)
UniBasel Contributors:Moffa, Giusi
Item Type:Article
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2041-1723
Last Modified:13 Apr 2021 14:33
Deposited On:13 Apr 2021 14:33

Repository Staff Only: item control page