Prominent Oncogenic Roles of EVI1 in Breast Carcinoma

Wang, Hui and Schaefer, Thorsten and Konantz, Martina and Braun, Martin and Varga, Zsuzsanna and Paczulla, Anna M. and Reich, Selina and Jacob, Francis and Perner, Sven and Moch, Holger and Fehm, Tanja N. and Kanz, Lothar and Schulze-Osthoff, Klaus and Lengerke, Claudia. (2017) Prominent Oncogenic Roles of EVI1 in Breast Carcinoma. Cancer Research, 77 (8). pp. 2148-2160.

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Official URL: https://edoc.unibas.ch/80793/

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Overexpression of the EVI1 oncogene is associated typically with aggressive myeloid leukemia, but is also detectable in breast carcinoma where its contributions are unexplored. Analyzing a tissue microarray of 608 breast carcinoma patient specimens, we documented EVI1 overexpression in both estrogen receptor-positive (ER; +; ) and estrogen receptor-negative (ER; -; ) breast carcinomas. Here, we report prognostic relevance of EVI1 overexpression in triple-negative breast carcinoma but not in the HER2-positive breast carcinoma subset. In human breast cancer cells, EVI1 silencing reduced proliferation, apoptosis resistance, and tumorigenicity, effects rescued by estrogen supplementation in ER; +; breast carcinoma cells. Estrogen addition restored ERK phosphorylation in EVI1-silenced cells, suggesting that EVI1 and estradiol signaling merge in MAPK activation. Conversely, EVI1 silencing had no effect on constitutive ERK activity in HER2; +; breast carcinoma cells. Microarray analyses revealed G-protein-coupled receptor (GPR) signaling as a prominent EVI1 effector mechanism in breast carcinoma. Among others, the GPR54-ligand KISS1 was identified as a direct transcriptional target of EVI1, which together with other EVI1-dependent cell motility factors such as RHOJ regulated breast carcinoma cell migration. Overall, our results establish the oncogenic contributions of EVI1 in ER- and HER2-negative subsets of breast cancer.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin
UniBasel Contributors:Konantz, Martina
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for Cancer Research
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Jun 2021 13:57
Deposited On:09 Jun 2021 13:57

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