Modeling hematopoietic disorders in zebrafish

Konantz, Martina and Schürch, Christoph and Hanns, Pauline and Müller, Joëlle S. and Sauteur, Loïc and Lengerke, Claudia. (2019) Modeling hematopoietic disorders in zebrafish. Disease models & mechanisms, 12 (9). dmm040360.

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Official URL: https://edoc.unibas.ch/80785/

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Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by; in vivo; imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin
UniBasel Contributors:Konantz, Martina
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:The Company of Biologists
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Jun 2021 13:21
Deposited On:09 Jun 2021 13:21

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