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Determination of carbapenem antibiotics using a purpose-made capillary electrophoresis instrument with contactless conductivity detection

Pham, Thi Ngoc Mai and Le, Thai Binh and Le, Duc Dung and Ha, Tran Hung and Nguyen, Ngoc Son and Pham, Tien Duc and Hauser, Peter C. and Nguyen, Thi Anh Huong and Mai, Thanh Duc . (2020) Determination of carbapenem antibiotics using a purpose-made capillary electrophoresis instrument with contactless conductivity detection. Journal of Pharmaceutical and Biomedical Analysis, 178. p. 112906.

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Official URL: https://edoc.unibas.ch/80572/

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Abstract

In this study, the employment of a purpose-made capillary electrophoresis (CE) instrument with capacitively coupled contactless conductivity detection ((CD)-D-4) as a simple and cost-effective approach for simultaneous determination of different carbapenem antibiotics is reported. The developed CE-(CD)-D-4 approach was for the first time applied for quality control of various pharmaceutical formulations in Vietnam, as well as for therapeutic monitoring of these antibiotics in plasma samples from patients under intensive care. Four of the most popular carbapenems in Vietnam, doripenem, meropenem, imipenem and ertapenem, were determined using an electrolyte composed of 10 mM Tris adjusted to pH 8.0 with acetic acid. The best detection limits achieved using the developed CE-(CD)-D-4 method were 0.36 mg/L and 0.45 mg/L for pharmaceutical and plasma samples, respectively. Good agreement between results from CE-(CD)-D-4 and the confirmation method (HPLC-PDA) was achieved, with a coefficient of determination (r(2)) for the two pairs of data of 0.9967. (C) 2019 Elsevier B.V. All rights reserved.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Analytische Chemie (Hauser)
UniBasel Contributors:Hauser, Peter C. P. C.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0731-7085
e-ISSN:1873-264X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:16 Feb 2021 14:12
Deposited On:16 Feb 2021 14:12

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