edoc

Low-cost and versatile analytical tool with purpose-made capillary electrophoresis coupled to contactless conductivity detection: Application to antibiotics quality control in Vietnam

Le, Thai Binh and Hauser, Peter C. and Pham, Thi Ngoc Mai and Kieu, Thi Lan Phuong and Le, Thi Phuong Quynh and Hoang, Quoc Anh and Le, Dinh Chi and Nguyen, Thi Anh Huong and Mai, Thanh Duc. (2020) Low-cost and versatile analytical tool with purpose-made capillary electrophoresis coupled to contactless conductivity detection: Application to antibiotics quality control in Vietnam. Electrophoresis, 41 (23). pp. 1980-1990.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/80568/

Downloads: Statistics Overview

Abstract

In this study, the development of our purpose-made capacitively coupled contactless conductivity detection ((CD)-D-4) for CE is reported. These systems have been employed as a simple, versatile, and cost-effective analytical tool. CE-(CD)-D-4 devices, whose principle is based on the control of the ion movements under an electrical field, can be constructed even with a modest financial budget and limited infrastructure. A featured application was developed for quality control of antimicrobial drugs using CE-(CD)-D-4, with most recent work on determination of aminoglycoside and glycopeptide antibiotics being communicated. For aminoglycosides, the development of CE-(CD)-D-4 methods was adapted to two categories. The first one includes drugs (liquid or powder form) for intravenous injection, containing either amikacin, streptomycin, kanamycin A, or kanamycin B. The second one covers drugs for eye drops (liquid or ointment form), containing either neomycin, tobramycin, or polymyxin. The CE-(CD)-D-4 method development was also made for determination of some popular glycopeptide antibiotics in Vietnam, including vancomycin and teicoplanin. The best detection limit achieved using the developed CE-(CD)-D-4 methods was 0.5 mg/L. Good agreement between results from CE-(CD)-D-4 and the confirmation method (HPLC- Photometric Diode Array ) was achieved, with their result deviations less than 8% and 13% for aminoglycoside and glycopeptide antibiotics, respectively.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Analytische Chemie (Hauser)
UniBasel Contributors:Hauser, Peter C. P. C.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0173-0835
e-ISSN:1522-2683
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:16 Feb 2021 11:10
Deposited On:16 Feb 2021 11:10

Repository Staff Only: item control page