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Application of Paramagnetic Lanthanoid Chelating Tags in NMR Spectroscopy and Their Use for the Localization of Ligands Within Biomacromolecules

Joss, Daniel and Vogel, Raphael and Zimmermann, Kaspar and Häussinger, Daniel. (2020) Application of Paramagnetic Lanthanoid Chelating Tags in NMR Spectroscopy and Their Use for the Localization of Ligands Within Biomacromolecules. In: Comprehensive Coordination Chemistry III. Amsterdam, pp. 1-29.

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Abstract

The application of paramagnetic lanthanoid chelating tags for the localization of ligands within biomacromolecules enables the elucidation of binding pockets and positioning of ligands within given targets of interest, a crucial prerequisite for rational drug design. This case study consists of an overview about lanthanoid chelating tags, a description of their structural properties, the induced anisotropy as well as approaches for the localization of ligands within biomacromolecules. The localization of sulfonamide inhibitors within human carbonic anhydrase II with an accuracy of up to 0.8 Å over distances of 22–38 Å using 19F pseudocontact shift is presented as a practical example.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Nuclear Magnetic Resonance (Häussinger)
UniBasel Contributors:Häussinger, Daniel
Item Type:Book Section
Book Section Subtype:Further Contribution in a Book
Publisher:Elsevier
ISBN:9780081026885
Note:Publication type according to Uni Basel Research Database: Book item
Language:English
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Last Modified:12 Feb 2021 09:03
Deposited On:08 Feb 2021 14:08

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