edoc

Fear conditioning in posttraumatic stress disorder : evidence for delayed extinction of autonomic, experiential, and behavioural responses

Blechert, Jens and Michael, Tanja and Vriends, Noortje and Margraf, Jürgen and Wilhelm, Frank H.. (2007) Fear conditioning in posttraumatic stress disorder : evidence for delayed extinction of autonomic, experiential, and behavioural responses. Behaviour research and therapy, 45 (9). pp. 2019-2033.

[img] PDF
Restricted to Repository staff only

250Kb

Official URL: http://edoc.unibas.ch/dok/A5250325

Downloads: Statistics Overview

Abstract

Aversive conditioning has been proposed as an important factor involved in the etiology of posttraumatic stress disorder (PTSD). However, it is not yet fully understood exactly which learning mechanisms are characteristic for PTSD. PTSD patients (n=36), and healthy individuals with and without trauma exposure (TE group, n=21; nTE group, n=34), underwent a differential fear conditioning experiment consisting of habituation, acquisition, and extinction phases. An electrical stimulus served as the unconditioned stimulus (US), and two neutral pictures as conditioned stimuli (CS+, paired; CS-, unpaired). Conditioned responses were quantified by skin conductance responses (SCRs), subjective ratings of CS valence and US-expectancy, and a behavioural test. In contrast to the nTE group, PTSD patients showed delayed extinction of SCRs to the CS+. Online ratings of valence and US-expectancy as well as the behavioural test confirmed this pattern. These findings point to a deficit in extinction learning and highlight the role of affective valence appraisals and cognitive biases in PTSD. In addition, there was some evidence that a subgroup of PTSD patients had difficulties in learning the CS-US contingency, thereby providing preliminary evidence of reduced discrimination learning.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Abteilung Klinische Psychologie und Psychiatrie
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Psychophysiologie (Wilhelm)
UniBasel Contributors:Wilhelm, Frank H and Michael, Tanja and Vriends, Noortje and Margraf, Jürgen
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0005-7967
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Related URLs:
Identification Number:
Last Modified:28 Sep 2017 14:39
Deposited On:22 Mar 2012 13:42

Repository Staff Only: item control page