Pharmacogenetic information in Swiss drug labels - a systematic analysis

Jeiziner, C. and Suter, K. and Wernli, U. and Barbarino, J. M. and Gong, L. and Whirl-Carrillo, M. and Klein, T. E. and Szucs, T. D. and Hersberger, K. E. and Meyer Zu Schwabedissen, H. E.. (2021) Pharmacogenetic information in Swiss drug labels - a systematic analysis. Pharmacogenomics Journal, 21 (4). pp. 423-434.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/80251/

Downloads: Statistics Overview


Implementation of pharmacogenetics (PGx) and individualization of drug therapy is supposed to obviate adverse drug reactions or therapy failure. Health care professionals (HCPs) use drug labels (DLs) as reliable information about drugs. We analyzed the Swiss DLs to give an overview on the currently available PGx instructions. We screened 4306 DLs applying natural language processing focusing on drug metabolism (pharmacokinetics) and we assigned PGx levels following the classification system of PharmGKB. From 5979 hits, 2564 were classified as PGx-relevant affecting 167 substances. 55% (n = 93) were classified as "actionable PGx". Frequently, PGx information appeared in the pharmacokinetics section and in DLs of the anatomic group "nervous system". Unstandardized wording, appearance of PGx information in different sections and unclear instructions challenge HCPs to identify and interpret PGx information and translate it into practice. HCPs need harmonization and standardization of PGx information in DLs to personalize drug therapies and tailor pharmaceutical care.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmaceutical Care (Hersberger)
UniBasel Contributors:Hersberger, Kurt E. and Jeiziner, Chiara and Meyer zu Schwabedissen, Henriette and Szucs, Thomas D.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:28 Sep 2021 09:33
Deposited On:28 Sep 2021 09:33

Repository Staff Only: item control page