Robot- and Laser-Assisted Bio-Sample Preparation: Development of an Integrated, Intuitive System

Duverney, Cédric and Abbasi, Hamed and Beltrán Bernal, Lina M. and Stauber, Tino and Snedeker, Jess G. and Cattin, Philippe C. and Zam, Azhar and Rauter, Georg. (2021) Robot- and Laser-Assisted Bio-Sample Preparation: Development of an Integrated, Intuitive System. In: New Trends in Medical and Service Robotics. MESROB 2020. Cham, pp. 219-226.

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The preparation of small-sized biological samples is traditionally performed manually utilizing mechanical tools such as scalpels. The main drawbacks of such methods are a lack of accuracy and repeatability of the resulting cuts and damage to the surrounding tissue due to the high interaction forces and the accompanying mechanical stresses. One way to circumvent these issues is to substitute the mechanical tools for laser light. When used in conjunction with a high-accuracy positioning system, such a preparation procedure enables repeatable cutting of arbitrary geometries while largely preserving the integrity of the surrounding tissue. In this paper, a system leveraging the potential of laser-based ablation for bio-sample preparation is proposed. It integrates and synchronizes all key components with extensive safety features and an intuitive user interface, allowing novice operators to perform sample preparations easily. As a first application, the proposed system has been utilized to create microdamages in mouse tail tendon fascicles. Promising results could be obtained, but careful tuning of the laser parameters and further optimization of the mechanical setup is still required to attain the high repeatability striven for.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedical Engineering > Laser and Robotics > Biomedical Laser and Optics (Zam)
UniBasel Contributors:Abbasi, Hamed
Item Type:Conference or Workshop Item, refereed
Conference or workshop item Subtype:Conference Paper
Publisher:Springer Nature Switzerland AG
Series Name:Mechanisms and Machine Science
Issue Number:93
Note:Publication type according to Uni Basel Research Database: Conference paper
Identification Number:
Last Modified:26 Jan 2021 09:36
Deposited On:26 Jan 2021 09:36

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