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NTRK2; methylation is related to reduced PTSD risk in two African cohorts of trauma survivors

Vukojevic, Vanja and Coynel, David and Ghaffari, Navid R. and Freytag, Virginie and Elbert, Thomas and Kolassa, Iris-Tatjana and Wilker, Sarah and McGaugh, James L. and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.. (2020) NTRK2; methylation is related to reduced PTSD risk in two African cohorts of trauma survivors. Proceedings of the National Academy of Sciences of the United States of America, 117 (35). pp. 21667-21672.

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Official URL: https://edoc.unibas.ch/79987/

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Abstract

Extensive pharmacologic, genetic, and epigenetic research has linked the glucocorticoid receptor (GR) to memory processes, and to risk and symptoms of posttraumatic stress disorder (PTSD). In the present study we investigated the epigenetic pattern of 12 genes involved in the regulation of GR signaling in two African populations of heavily traumatized individuals: Survivors of the rebel war in northern Uganda (; n; = 463) and survivors of the Rwandan genocide (; n; = 350). The strongest link between regional methylation and PTSD risk and symptoms was observed for; NTRK2; , which encodes the transmembrane receptor tropomyosin-related kinase B, binds the brain-derived neurotrophic factor, and has been shown to play an important role in memory formation.; NTRK2; methylation was not related to trauma load, suggesting that methylation differences preexisted the trauma. Because; NTRK2; methylation differences were predominantly associated with memory-related PTSD symptoms, and because they seem to precede traumatic events, we next investigated the relationship between; NTRK2; methylation and memory in a sample of nontraumatized individuals (; n; = 568). We found that; NTRK2; methylation was negatively associated with recognition memory performance. Furthermore, fMRI analyses revealed; NTRK2; methylation-dependent differences in brain network activity related to recognition memory. The present study demonstrates that; NTRK2; is epigenetically linked to memory functions in nontraumatized subjects and to PTSD risk and symptoms in traumatized populations.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
ISSN:0027-8424
e-ISSN:1091-6490
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:29 Dec 2020 13:57
Deposited On:29 Dec 2020 13:57

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