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Novel CPET Reference Values in Healthy Adults: Associations with Physical Activity

Wagner, Jonathan and Knaier, Raphael and Infanger, Denis and Königstein, Karsten and Klenk, Christopher and Carrard, Justin and Hanssen, Henner and Hinrichs, Timo and Seals, Douglas and Schmidt-Trucksäss, Arno. (2021) Novel CPET Reference Values in Healthy Adults: Associations with Physical Activity. Medicine and Science in Sports and Exercise, 53 (1). pp. 26-37.

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Official URL: https://edoc.unibas.ch/79941/

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Abstract

Cardiopulmonary exercise testing (CPET) is an important measurement in clinical practice and its primary outcome, maximal oxygen uptake (V[Combining Dot Above]O2peak), is inversely associated with morbidity and mortality. The purpose of this study is to provide CPET reference values for maximal and submaximal parameters across the adult age spectrum of a healthy European cohort, to compare V[Combining Dot Above]O2peak values with other reference datasets and to analyze the associations between physical activity (PA) levels and CPET parameters.; In this cross-sectional study, we prospectively recruited 502 participants (47% female) from 20 to 90 years old. The subjects performed a CPET on a cycle ergometer using a ramp protocol. PA was objectively and continuously measured over 14 days using a triaxial accelerometer. Quantile curves were calculated for CPET parameters. To investigate the associations between CPET parameters and PA levels, linear regression analysis was performed.; V[Combining Dot Above]O2peak values observed in the group of 20-29 years were 46.6±7.9 and 39.3±6.5 (mL/kg/min) for males and females, respectively. On average, each age category (10-year increments) showed a 10% lower V[Combining Dot Above]O2peak relative to the next younger age category. V[Combining Dot Above]O2peak values of previous studies were, on average 7.5 (mL/kg/min) (20%) lower for males and 6.5 (mL/kg/min) (21%) lower for females. There was strong evidence supporting a positive association between V[Combining Dot Above]O2peak (mL/kg/min) and the level of habitual PA performed at vigorous PA (estimate 0.26; p < 0.001].; Maximal and submaximal CPET reference values over a large age range are novel and differences to other studies are clinically highly relevant. Objectively measured vigorous-intensity PA showed a strong positive association with higher V[Combining Dot Above]O2peak and other performance-related CPET parameters, supporting the implementation of higher intensity aerobic exercise in health promotion.
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Sportmedizin (Schmidt-Trucksäss)
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit
UniBasel Contributors:Hinrichs, Timo and Wagner, Jonathan and Carrard, Justin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott, Williams & Wilkins
ISSN:0195-9131
e-ISSN:1530-0315
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2021 03:10
Deposited On:05 Feb 2021 10:13

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