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Genome-wide Association Study of Postoperative Cognitive Dysfunction in Older Surgical Patients

Rickenbacher, Marc and Reinbold, Céline S. and Herms, Stefan and Hoffmann, Per and Cichon, Sven and Wueest, Alexandra S. and Monsch, Andreas U. and Steiner, Luzius A. and Goettel, Nicolai. (2022) Genome-wide Association Study of Postoperative Cognitive Dysfunction in Older Surgical Patients. Journal of neurosurgical anesthesiology, 34 (2). pp. 248-250.

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Official URL: https://edoc.unibas.ch/79884/

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Abstract

Postoperative cognitive dysfunction (POCD) is a common neurocognitive disorder after surgery and anesthesia, particularly in elderly patients. Various studies have suggested genetic risk factors for POCD. The study aimed to detect genome-wide associations of POCD in older patients.; In this prospective observational cohort study, participants aged 65 years and above completed a set of neuropsychological tests before, at 1 week, and 3 months after major noncardiac surgery. Test variables were converted into standard scores (z-scores) based on demographic characteristics. POCD was diagnosed if the decline was >1 SD in ≥2 of the 15 variables in the assessment battery. A genome-wide association study (GWAS) was performed to determine potential alleles that are linked to the POCD phenotype. In addition, candidate genes for POCD were identified in a literature search for further analysis.; Sixty-three patients with blood samples were included in the study. POCD was diagnosed in 47.6% of patients at 1 week and in 34.2% of patients at 3 months after surgery. Insufficient sample quality led to exclusion of 26 patients. In the remaining 37 patients, a GWAS was performed, but no association (P<5×10) with POCD was found. The subsequent gene set enrichment analysis of 34 candidate genes did not reveal any significant associations.; In this patient cohort, a GWAS did not reveal an association between specific genetic alleles and POCD at 1 week and 3 months after surgery. Future genetic analysis should focus on specific candidate genes for POCD. What do you want to do ? New mail Copy What do you want to do ? New mail Copy
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie > Geriatrie (Kressig)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie > Geriatrie (Kressig)
07 Faculty of Psychology > Departement Psychologie
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Neuroscience (Papassotiropoulos)
UniBasel Contributors:Monsch, Andreas U. U
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
ISSN:0898-4921
e-ISSN:1537-1921
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Mar 2022 07:28
Deposited On:30 Mar 2022 07:28

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