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Apolipoprotein E allele frequencies in argyrophilic grain disease

Tolnay, Markus and Probst, A. and Monsch, Andreas U. and Staehelin, Hannes B. and Egensperger, Rupert. (1998) Apolipoprotein E allele frequencies in argyrophilic grain disease. Acta neuropathologica, 96 (3). pp. 225-227.

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Official URL: https://edoc.unibas.ch/79862/

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Abstract

Apolipoprotein E (ApoE) genotypes were analyzed in 35 subjects with argyrophilic grain diseases (AgD). Neuropathologically, all cases were characterized by abundant argyrophilic grains in the hippocampus and in the entorhinal or parahippocampal cortex. We found an ApoE epsilon4 allele frequency of 0.007 in AgD patients, which is significantly different from the epsilon4 allele frequencies reported in age-matched Alzheimer's disease (AD) patients (0.24), but not from age-matched controls (0.09). We conclude that the ApoE epsilon4 allele does not constitute a risk factor for the development of AgD. Our results further suggest that AgD is a progressive disorder differentiated from AD by morphological and genetic criteria. What do you want to do ? New mail Copy
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie > Geriatrie (Kressig)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie > Geriatrie (Kressig)
07 Faculty of Psychology > Departement Psychologie
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Monsch, Andreas U. U
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:0001-6322
e-ISSN:1432-0533
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Dec 2020 08:47
Deposited On:21 Dec 2020 08:47

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