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Battling Bacteria with Free and Surface-Immobilized Polymeric Nanostructures

Rigo , Serena and Kyropoulou , Myrto and Schoenenberger , Cora-Ann and Palivan , Cornelia G.. (2020) Battling Bacteria with Free and Surface-Immobilized Polymeric Nanostructures. In: Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies. Cham, pp. 385-408.

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Official URL: https://edoc.unibas.ch/79770/

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Abstract

With the discovery of antibiotics, bacterial infections and previously fatal diseases suddenly became curable. During the golden era of antibiotics, new classes of antibiotics were discovered. However, antibiotic-resistant bacteria rapidly evolved while fewer new antimicrobial drugs were discovered and marketed. Today, a growing number of infections are becoming harder to treat as the bacterial resistance is spreading and antibiotics become less effective. Evidently, there is an urgent demand for new strategies that efficiently battle pathogenic bacteria. Among emerging technologies, those involving polymeric nanostructures, especially polymersomes, offer many features that make them attractive candidates for battling infections. Polymersomes can be designed to be biocompatible and respond to various environmental signals. They are more robust than liposomes and can host hydrophobic and hydrophilic antimicrobial compounds, which can be released and act locally. Last but not least, they are biodegradable. Moreover, platforms comprising polymeric nanostructures can be designed as sensors for diagnosing infections. Many of these approaches require the immobilization of the antimicrobial nanostructures on a surface whereby the activity is localized to a specific region. Several recent examples of polymeric nanostructures with antimicrobial activity, both free in solution or immobilized on surfaces, are highlighted and discussed in this chapter.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Publisher:Springer International Publishing
ISBN:978-3-030-34474-0
e-ISBN:978-3-030-34475-7
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:01 Mar 2021 13:04
Deposited On:01 Mar 2021 13:04

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