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Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

Chimisso, Vittoria and Aleman Garcia, Miguel Angel and Yorulmaz Avsar, Saziye and Dinu, Ionel Adrian and Palivan, Cornelia G.. (2020) Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice. Molecules, 25 (18). p. 4090.

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Abstract

Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G and Chimisso, Vittoria and Aleman Garcia, Miguel Angel and Yorulmaz Avsar, Saziye and Schönenberger, Cora-Ann
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1420-3049
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:16 Dec 2021 04:10
Deposited On:02 Mar 2021 12:17

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