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Asymmetric β-Methylation of l- and d-α-Amino Acids by a Self-Contained Enzyme Cascade

Liao, Cangsong and Seebeck, Florian P.. (2020) Asymmetric β-Methylation of l- and d-α-Amino Acids by a Self-Contained Enzyme Cascade. Angewandte Chemie International Edition, 59 (18). pp. 7184-7187.

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Official URL: https://edoc.unibas.ch/79597/

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Abstract

This report describes a modular enzyme-catalyzed cascade reaction that transforms l- or d-α-amino acids to β-methyl-α-amino acids. In this process an α-amino acid transaminase, an α-keto acid methyltransferase, and a halide methyltransferase cooperate in two orthogonal reaction cycles that mediate product formation and regeneration of the cofactor pyridoxal-5'-phosphate and the co-substrate S-adenosylmethionine. The only stoichiometric reagents consumed in this process are the unprotected l- or d-α-amino acid and methyl iodide.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
UniBasel Contributors:Liao, Cangsong and Seebeck, Florian Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1433-7851
e-ISSN:1521-3773
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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edoc DOI:
Last Modified:27 Apr 2021 01:30
Deposited On:03 Mar 2021 09:08

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