Membraneless organelles: phasing out of equilibrium

Hondele, Maria and Heinrich, Stephanie and De Los Rios, Paolo and Weis, Karsten. (2020) Membraneless organelles: phasing out of equilibrium. Emerging topics in life sciences, 4 (3). pp. 343-354.

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Official URL: https://edoc.unibas.ch/79408/

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Over the past years, liquid-liquid phase separation (LLPS) has emerged as a ubiquitous principle of cellular organization implicated in many biological processes ranging from gene expression to cell division. The formation of biological condensates, like the nucleolus or stress granules, by LLPS is at its core a thermodynamic equilibrium process. However, life does not operate at equilibrium, and cells have evolved multiple strategies to keep condensates in a non-equilibrium state. In this review, we discuss how these non-equilibrium drivers counteract solidification and potentially detrimental aggregation, and at the same time enable biological condensates to perform work and control the flux of substrates and information in a spatial and temporal manner.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hondele)
UniBasel Contributors:Hondele, Maria
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Portland Press
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:27 Jan 2022 14:02
Deposited On:27 Jan 2022 14:00

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