edoc

Diverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks

Zenke, Friedemann and Agnes, Everton J. and Gerstner, Wulfram. (2015) Diverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks. Nature Communications, 6. p. 6922.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/79141/

Downloads: Statistics Overview

Abstract

Synaptic plasticity, the putative basis of learning and memory formation, manifests in various forms and across different timescales. Here we show that the interaction of Hebbian homosynaptic plasticity with rapid non-Hebbian heterosynaptic plasticity is, when complemented with slower homeostatic changes and consolidation, sufficient for assembly formation and memory recall in a spiking recurrent network model of excitatory and inhibitory neurons. In the model, assemblies were formed during repeated sensory stimulation and characterized by strong recurrent excitatory connections. Even days after formation, and despite ongoing network activity and synaptic plasticity, memories could be recalled through selective delay activity following the brief stimulation of a subset of assembly neurons. Blocking any component of plasticity prevented stable functioning as a memory network. Our modelling results suggest that the diversity of plasticity phenomena in the brain is orchestrated towards achieving common functional goals.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology
UniBasel Contributors:Agnes, Everton Joao
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2041-1723
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:13 Nov 2020 08:43
Deposited On:13 Nov 2020 08:43

Repository Staff Only: item control page