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Pharmacogenetic modeling of human cytochrome P450 2D6; On the force of variation in inducing toxicity

Don, Charleen Gerogette. Pharmacogenetic modeling of human cytochrome P450 2D6; On the force of variation in inducing toxicity. 2020, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: https://edoc.unibas.ch/78881/

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Abstract

Understanding the way in which drugs are metabolized by CYP2D6 and hence the underlying mechanisms that define potential toxicity is crucial to avoid adverse reactions. The high occurrence of CYP2D6 polymorphs enhances the complexity of the toxicity assessment of a drug candidate and should be tackled from early drug discovery phase on. The research described in this PhD thesis has been performed to provide novel fundamental insights regarding the metabolic activity of CYP2D6 wild-type and several polymorphs using various state-of-the-art in silico techniques. The results of the CYP2D6-focused studies enhance our knowledge regarding the enzyme particularities, and can be used to accelerate the development of CYP2D6 modeling tools with more accurate and reliable predictions.
Advisors:Ricklin, Daniel and Smiesko, Martin and Geerke, Daan P.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular Pharmacy (Ricklin)
UniBasel Contributors:Ricklin, Daniel and Smiesko, Martin
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:13768
Thesis status:Complete
Number of Pages:220
Language:English
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss137688
edoc DOI:
Last Modified:27 Jan 2021 15:45
Deposited On:27 Jan 2021 15:45

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