Safety of liver donation after fatal intoxication with the tricyclic antidepressant trimipramine

Fattinger, K. E. and Rentsch, K. M. and Meier, P. J. and Dazzi, H. and Krähenbühl, S.. (1996) Safety of liver donation after fatal intoxication with the tricyclic antidepressant trimipramine. Transplantation, Vol. 62, H. 9. pp. 1259-1262.

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Official URL: http://edoc.unibas.ch/dok/A5261725

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We report the case of a patient receiving long-term treatment with the tricyclic antidepressant trimipramine who died 10 days after a trimipramine overdose. A few hours before death, the serum trimipramine concentration had fallen to 80 microg/L. Similar values are reported for patients taking therapeutic trimipramine doses. At this serum concentration, the liver content of trimipramine and it's 2-hydroxy and N-desmethyl metabolites was 1750 microg/kg, 850 microg/kg, and 225 microg/kg, respectively. The liver was morphologically normal. Back calculations suggest that a liver transplant obtained from a donor dying from a trimipramine overdose should be safe, if the serum trimipramine concentration has fallen below 2000 microg/L. If higher serum trimipramine concentrations are present, harvesting should be delayed to avoid trimipramine toxicity in the recipient.
Faculties and Departments:11 Rektorat und Verwaltung > Vizerektorat Forschung
UniBasel Contributors:Meier-Abt, Peter J.
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:41

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