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Antibacterial and ATP synthesis modulating compounds from Salvia tingitana

Bisio, Angela and Schito, Anna M. and Pedrelli, Francesca and Danton, Ombeline and Reinhardt, Jakob K. and Poli, Giulio and Tuccinardi, Tiziano and Bürgi, Thomas and De Riccardis, Francesco and Giacomini, Mauro and Calzia, Daniela and Panfoli, Isabella and Schito, Gian Carlo and Hamburger, Matthias and De Tommasi, Nunziatina. (2020) Antibacterial and ATP synthesis modulating compounds from Salvia tingitana. Journal of Natural Products, 83 (4). pp. 1027-1042.

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Official URL: https://edoc.unibas.ch/78658/

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Abstract

A surface extract of the aerial parts of Salvia tingitana afforded a nor-sesterterpenoid (1) and eight new sesterterpenoids (2–̵9), along with five known sesterterpenoids, five labdane and one abietane diterpenoid, one sesquiterpenoid, and four flavonoids. The structures of the new compounds were established by 1D and 2D NMR spectroscopy, HRESIMS, and VCD data and Mosher’s esters analysis. The antimicrobial activity of compounds was evaluated against 30 human pathogens including 27 clinical strains and three isolates of marine origin for their possible implications on human health. The methyl ester of salvileucolide (10), salvileucolide-6,23-lactone (11), sclareol (15), and manool (17) were the most active against Gram-positive bacteria. The compounds were also tested for the inhibition of ATP production in purified mammalian rod outer segments. Terpenoids 10, 11, 15, and 17 inhibited ATP production, while only 17 inhibited also ATP hydrolysis. Molecular modeling studies confirmed the capacity of 17 to interact with mammalian ATP synthase. A significant reduction of ATP production in the presence of 17 was observed in Enterococcus faecalis and E. faecium isolates.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias and Danton, Ombeline Réjane and Reinhardt, Jakob Klaus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:0163-3864
e-ISSN:1520-6025
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Nov 2021 15:31
Deposited On:01 Nov 2021 15:31

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