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Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

Valent, Peter and Akin, Cem and Hartmann, Karin and Nilsson, Gunnar and Reiter, Andreas and Hermine, Olivier and Sotlar, Karl and Sperr, Wolfgang R. and Escribano, Luis and George, Tracy I. and Kluin-Nelemans, Hanneke C. and Ustun, Celalettin and Triggiani, Massimo and Brockow, Knut and Gotlib, Jason and Orfao, Alberto and Kovanen, Petri T. and Hadzijusufovic, Emir and Sadovnik, Irina and Horny, Hans-Peter and Arock, Michel and Schwartz, Lawrence B. and Austen, K. Frank and Metcalfe, Dean D. and Galli, Stephen J.. (2020) Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts. Theranostics, 10 (23). pp. 10743-10768.

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Official URL: https://edoc.unibas.ch/78656/

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Abstract

The origin and functions of mast cells (MCs) have been debated since their description by Paul Ehrlich in 1879. MCs have long been considered 'reactive bystanders' and 'amplifiers' in inflammatory processes, allergic reactions, and host responses to infectious diseases. However, knowledge about the origin, phenotypes and functions of MCs has increased substantially over the past 50 years. MCs are now known to be derived from multipotent hematopoietic progenitors, which, through a process of differentiation and maturation, form a unique hematopoietic lineage residing in multiple organs. In particular, MCs are distinguishable from basophils and other hematopoietic cells by their unique phenotype, origin(s), and spectrum of functions, both in innate and adaptive immune responses and in other settings. The concept of a unique MC lineage is further supported by the development of a distinct group of neoplasms, collectively referred to as mastocytosis, in which MC precursors expand as clonal cells. The clinical consequences of the expansion and/or activation of MCs are best established in mastocytosis and in allergic inflammation. However, MCs have also been implicated as important participants in a number of additional pathologic conditions and physiological processes. In this article, we review concepts regarding MC development, factors controlling MC expansion and activation, and some of the fundamental roles MCs may play in both health and disease. We also discuss new concepts for suppressing MC expansion and/or activation using molecularly-targeted drugs.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:IVY Spring
ISSN:1838-7640
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Jun 2022 15:17
Deposited On:02 Jun 2022 15:17

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