Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Fritsche, Ellen and Grandjean, Philippe and Crofton, Kevin M. and Aschner, Michael and Goldberg, Alan and Heinonen, Tuula and Hessel, Ellen V. S. and Hogberg, Helena T. and Bennekou, Susanne Hougaard and Lein, Pamela J. and Leist, Marcel and Mundy, William R. and Paparella, Martin and Piersma, Aldert H. and Sachana, Magdalini and Schmuck, Gabriele and Solecki, Roland and Terron, Andrea and Monnet-Tschudi, Florianne and Wilks, Martin F. and Witters, Hilda and Zurich, Marie-Gabrielle and Bal-Price, Anna. (2018) Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicology and applied pharmacology, 354. pp. 3-6.

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Official URL: https://edoc.unibas.ch/78575/

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This consensus statement voices the agreement of scientific stakeholders from regulatory agencies, academia and industry that a new framework needs adopting for assessment of chemicals with the potential to disrupt brain development. An increased prevalence of neurodevelopmental disorders in children has been observed that cannot solely be explained by genetics and recently pre- and postnatal exposure to environmental chemicals has been suspected as a causal factor. There is only very limited information on neurodevelopmental toxicity, leaving thousands of chemicals, that are present in the environment, with high uncertainty concerning their developmental neurotoxicity (DNT) potential. Closing this data gap with the current test guideline approach is not feasible, because the in vivo bioassays are far too resource-intensive concerning time, money and number of animals. A variety of in vitro methods are now available, that have the potential to close this data gap by permitting mode-of-action-based DNT testing employing human stem cells-derived neuronal/glial models. In vitro DNT data together with in silico approaches will in the future allow development of predictive models for DNT effects. The ultimate application goals of these new approach methods for DNT testing are their usage for different regulatory purposes.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Regulatory Toxicology (Wilks)
UniBasel Contributors:Wilks, Martin F.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Academic Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Oct 2020 06:53
Deposited On:05 Oct 2020 06:53

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