Phospholipid-Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability

Zong, Wei and Thingholm, Bo and Itel, Fabian and Schattling, Philipp S. and Brodszkij, Edit and Mayer, Daniel and Stenger, Steffen and Goldie, Kenneth N. and Han, Xiaojun and Städler, Brigitte. (2018) Phospholipid-Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability. Langmuir, 34 (23). pp. 6874-6886.

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Official URL: https://edoc.unibas.ch/78560/

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The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes while overcoming their challenges. We report the synthesis of poly(cholesteryl methacrylate)- block-poly(2-(dimethylamino) ethyl methacrylate) (pCMA- b-pDMAEMA) block copolymers and their assembly with phospholipids into hybrid vesicles. Their geometry, their ζ-potential, and their ability to adsorb onto polymer-coated surfaces were assessed. Giant unilamellar vesicles were employed to confirm the presence of both the phospholipids and the block copolymer in the same membrane. Furthermore, the cytotoxicity of selected hybrid vesicles was determined in RAW 264.7 mouse macrophages, primary rat Kupffer cells, and human macrophages. The internalization and lysosomal escape ability of the hybrid vesicles were confirmed using RAW 264.7 mouse macrophages. Taken together, our findings illustrate that the reported hybrid vesicles are a promising complementary drug delivery platform for existing liposomes and polymersomes.
Faculties and Departments:05 Faculty of Science
UniBasel Contributors:Goldie, Kenneth N.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Oct 2020 14:28
Deposited On:01 Oct 2020 07:41

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