Rapid Structure Determination of Microcrystalline Molecular Compounds Using Electron Diffraction

Gruene, Tim and Wennmacher, Julian T. C. and Zaubitzer, Christan and Holstein, Julian J. and Heidler, Jonas and Fecteau-Lefebvre, Ariane and De Carlo, Sacha and Müller, Elisabeth and Goldie, Kenneth N. and Regeni, Irene and Li, Teng and Santiso-Quinones, Gustavo and Steinfeld, Gunther and Handschin, Stephan and van Genderen, Eric and van Bokhoven, Jeroen A. and Clever, Guido H. and Pantelic, Radosav. (2018) Rapid Structure Determination of Microcrystalline Molecular Compounds Using Electron Diffraction. Angewandte Chemie International Edition, 57 (50). pp. 16313-16317.

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Official URL: https://edoc.unibas.ch/78558/

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Chemists of all fields currently publish about 50 000 crystal structures per year, the vast majority of which are X-ray structures. We determined two molecular structures by employing electron rather than X-ray diffraction. For this purpose, an EIGER hybrid pixel detector was fitted to a transmission electron microscope, yielding an electron diffractometer. The structure of a new methylene blue derivative was determined at 0.9 Å resolution from a crystal smaller than 1×2 μm; 2; . Several thousand active pharmaceutical ingredients (APIs) are only available as submicrocrystalline powders. To illustrate the potential of electron crystallography for the pharmaceutical industry, we also determined the structure of an API from its pill. We demonstrate that electron crystallography complements X-ray crystallography and is the technique of choice for all unsolved cases in which submicrometer-sized crystals were the limiting factor.
Faculties and Departments:05 Faculty of Science
UniBasel Contributors:Goldie, Kenneth N.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Oct 2020 07:24
Deposited On:01 Oct 2020 07:24

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