A worldwide comparison of the management of surgical treatment of advanced oral cancer

Kansy, Katinka and Mueller, Andreas Albert and Mücke, Thomas and Koersgen, Friederike and Wolff, Klaus Dietrich and Zeilhofer, Hans Florian and Hölzle, Frank and Pradel, Winnie and Schneider, Matthias and Kolk, Andreas and Smeets, Ralf and Acero, Julio and Haers, Piet and Ghali, G. E. and Hoffmann, Jürgen. (2018) A worldwide comparison of the management of surgical treatment of advanced oral cancer. Journal of Cranio-Maxillofacial Surgery, 46 (3). pp. 511-520.

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Official URL: https://edoc.unibas.ch/78394/

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Introduction: Microvascular surgery following tumor resection has become an important field of oral and maxillofacial surgery (OMFS). Following the results from management of T1/T2 floor-of-mouth and tongue squamous cell carcinoma (SCC) in German-speaking countries, Europe, and worldwide, this paper presents specific concepts for the management of resection and reconstruction of T3/T4 SCC of the maxillary and mandibular alveolar process and tongue. Methods: The D`OSAK questionnaire was distributed in three different phases to a growing number of maxillofacial units worldwide. Within this survey, clinical patient settings were presented to participants and center-specific treatment strategies were evaluated. Results: A total of 188 OMFS units from 36 different countries documented their treatment strategies for T3/T4 maxillary and mandibular alveolar process and tongue SCC. The extent of surgical resections and subsequent reconstructions is more consistent than with T1/T2 tumors, although the controversy surrounding continuity resections and mandible-sparing procedures remains. For continuity resection of the mandible the fibula free flap is the most frequently used bone replacement, whereas maxilla reconstruction concepts are less consistent, ranging from locoregional coverage concepts and different microvascular reconstruction options to treatment via obturator prosthesis. Conclusion: Results from treatment strategies for T3/T4 tumors underline the limited evidence for the appropriate amount of resection and subsequent reconstruction process, especially in cases involving the mandible. Prospective randomized trials will be necessary in the long term to establish valid treatment guidelines.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Kopfbereich > Cleft lip and palate surgery (Müller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Kopfbereich > Cleft lip and palate surgery (Müller)
UniBasel Contributors:Müller, Andreas A.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Sep 2020 09:10
Deposited On:29 Sep 2020 09:10

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