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Point-of-care ultrasound in the diagnosis of melioidosis in Laos

Huson, Michaëla A. M. and Kling, Kerstin and Chankongsin, Somaphone and Phongluxa, Khampheng and Keoluangkhot, Valy and Newton, Paul N. and Dance, David and Heller, Tom and Neumayr, Andreas. (2020) Point-of-care ultrasound in the diagnosis of melioidosis in Laos. American Journal of Tropical Medicine and Hygiene, 103 (2). pp. 675-678.

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Official URL: https://edoc.unibas.ch/78373/

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Abstract

Melioidosis is endemic in many rural areas in Southeast Asia where facilities for culture and identification of; Burkholderia pseudomallei; are often limited. We performed a prospective observational study in patients presenting with fever to Mahosot Hospital, the primary referral hospital in Laos, to establish whether the detection of abscesses on ultrasound could support a presumptive diagnosis of melioidosis. All patients underwent ultrasound examination to detect abscesses in the liver, spleen, prostate, or, if indicated, subcutaneous tissue. We enrolled 153 patients, including 18 patients with melioidosis. Of these, 11 (61%) had an abscess at one or more sites, including five (28%) with splenic and/or liver abscesses. Absence of abscesses cannot rule out melioidosis, but the positive predictive value of abscesses for melioidosis was high at 93% (88-96%). Therefore, in endemic areas, the presence of abscesses in febrile patients should prompt empiric antibiotic therapy for melioidosis even in the absence of culture confirmation.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Neumayr, Andreas and Kling, Kerstin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society of Tropical Medicine and Hygiene
ISSN:0002-9637
e-ISSN:1476-1645
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Jan 2021 09:40
Deposited On:04 Jan 2021 09:40

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