edoc

Insulin regulates the expression of the insulin-like growth factor binding protein 2 mRNA in rat hepatocytes

Böni-Schnetzler, M. and Schmid, C. and Mary, J. L. and Zimmerli, B. and Meier, P. J. and Zapf, J. and Schwander, J. and Froesch, E. R.. (1990) Insulin regulates the expression of the insulin-like growth factor binding protein 2 mRNA in rat hepatocytes. Molecular endocrinology, Vol. 4, H. 9. pp. 1320-1326.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5261773

Downloads: Statistics Overview

Abstract

The goal of this study was to find out whether GH or insulin regulate the mRNA expression of the fetal binding protein of insulin-like growth factor (IGFBP-2). Primary hepatocytes from adult rats were used as a test system. IGFBP-2 mRNA was abundant in cells cultured in the absence of hormones and markedly reduced in cultures containing insulin. Addition of GH had no effect on IGFBP-2 mRNA levels although the cells are responsive to GH as demonstrated by a GH mediated elevation of IGF l mRNA levels. Half-maximal down-regulation of IGFBP-2 mRNA levels occurred at an insulin concentration of 1 to 2 x 10(-10) M. The finding that insulin is a potent negative regulator of hepatic IGFBP-2 mRNA levels suggests a physiologically important regulatory link between the two hormones insulin and IGF l.
Faculties and Departments:11 Rektorat und Verwaltung > Vizerektorat Forschung
UniBasel Contributors:Meier-Abt, Peter J.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:The Endocrine Society
ISSN:0888-8809
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:41

Repository Staff Only: item control page