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First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study

Tschopp, Jonathan and L'Huillier, Arnaud G. and Mombelli, Matteo and Mueller, Nicolas J. and Khanna, Nina and Garzoni, Christian and Meloni, Dario and Papadimitriou-Olivgeris, Matthaios and Neofytos, Dionysios and Hirsch, Hans H. and Schuurmans, Mace M. and Mueller, Thomas and Berney, Thierry and Steiger, Juerg and Pascual, Manuel and Manuel, Oriol and van Delden, Christian and Swiss Transplant Cohort Study, . (2020) First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study. American Journal of Transplantation, 20 (10). pp. 2876-2882.

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Official URL: https://edoc.unibas.ch/77936/

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Abstract

Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, comprehensive data of SARS-CoV-2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety-five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow-up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS-CoV-2 infection in middle-aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft > Pflegewissenschaft (De Geest)
UniBasel Contributors:De Geest, Sabina M.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1600-6135
e-ISSN:1600-6143
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Dec 2020 09:34
Deposited On:30 Dec 2020 09:34

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