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AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer - a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Ferastraoaru, D. and Bax, H. J. and Bergmann, C. and Capron, M. and Castells, M. and Dombrowicz, D. and Fiebiger, E. and Gould, H. J. and Hartmann, K. and Jappe, U. and Jordakieva, G. and Josephs, D. H. and Levi-Schaffer, F. and Mahler, V. and Poli, A. and Rosenstreich, D. and Roth-Walter, F. and Shamji, M. and Steveling-Klein, E. H. and Turner, M. C. and Untersmayr, E. and Karagiannis, S. N. and Jensen-Jarolim, E.. (2020) AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer - a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI). Clinical and Translational Allergy, 10 (32). p. 32.

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Official URL: https://edoc.unibas.ch/77921/

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Abstract

Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Nature
ISSN:2045-7022
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Jan 2022 12:47
Deposited On:27 Jan 2022 12:47

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