Measuring and reporting treatment adherence: What can we learn by comparing two respiratory conditions?

Tibble, Holly and Flook, Mary and Sheikh, Aziz and Tsanas, Athanasios and Horne, Rob and Vrijens, Bernard and De Geest, Sabina and Stagg, Helen R.. (2021) Measuring and reporting treatment adherence: What can we learn by comparing two respiratory conditions? British Journal of Clinical Pharmacology, 87 (3). pp. 825-836.

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Official URL: https://edoc.unibas.ch/77848/

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Medication non-adherence, defined as any deviation from the regimen recommended by their healthcare provider, can increase morbidity, mortality, and side effects, while reducing effectiveness. Through studying two respiratory conditions, asthma and tuberculosis (TB), we thoroughly review the current understanding of the measurement and reporting of medication adherence. In this paper, we identify major methodological issues in the standard ways that adherence has been conceptualised, defined and studied in asthma and TB. Between- and within- the two diseases there are substantial variations in adherence reporting, linked to differences in dosing intervals and treatment duration. Critically, the communicable nature of TB has resulted in dose-by-dose monitoring becoming a recommended treatment standard. Through the lens of these similarities and contrasts, we highlight contemporary shortcomings in the generalised conceptualisation of medication adherence. Furthermore, we outline elements in which knowledge could be directly transferred from one condition to the other, such as the application of large-scale cost-effective monitoring methods in TB to resource-poor settings in asthma. To develop a more robust evidence-based approach, we recommend the use of standard taxonomies detailed in the ABC Taxonomy when measuring and discussing adherence. Regimen and intervention development and use should be based on sufficient evidence of the commonality and type of adherence behaviours displayed by patients with the relevant condition. A systematic approach to the measurement and reporting of adherence could improve the value and generalisability of research across all health conditions.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
UniBasel Contributors:De Geest, Sabina M.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2021 09:40
Deposited On:22 Mar 2021 09:40

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