edoc

Impact of different mass drug administration strategies for gaining and sustaining control of Schistosoma mansoni and Schistosoma haematobium infection in Africa

King, Charles H. and Kittur, Nupur and Binder, Sue and Campbell, Carl H. and N'Goran, Eliézer K. and Meite, Aboulaye and Utzinger, Jürg and Olsen, Annette and Magnussen, Pascal and Kinung'hi, Safari and Fenwick, Alan and Phillips, Anna E. and Gazzinelli-Guimaraes, Pedro H. and Dhanani, Neerav and Ferro, Josefo and Karanja, Diana M. S. and Mwinzi, Pauline N. M. and Montgomery, Susan P. and Wiegand, Ryan E. and Secor, William Evan and Hamidou, Amina A. and Garba, Amadou and Colley, Daniel G.. (2020) Impact of different mass drug administration strategies for gaining and sustaining control of Schistosoma mansoni and Schistosoma haematobium infection in Africa. American journal of tropical medicine and hygiene, 103 (Suppl 1.). pp. 14-23.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/77844/

Downloads: Statistics Overview

Abstract

This report summarizes the design and outcomes of randomized controlled operational research trials performed by the Bill & Melinda Gates Foundation-funded Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) from 2009 to 2019. Their goal was to define the effectiveness and test the limitations of current WHO-recommended schistosomiasis control protocols by performing large-scale pragmatic trials to compare the impact of different schedules and coverage regimens of praziquantel mass drug administration (MDA). Although there were limitations to study designs and performance, analysis of their primary outcomes confirmed that all tested regimens of praziquantel MDA significantly reduced local; Schistosoma; infection prevalence and intensity among school-age children. Secondary analysis suggested that outcomes in locations receiving four annual rounds of MDA were better than those in communities that had treatment holiday years, in which no praziquantel MDA was given. Statistical significance of differences was obscured by a wider-than-expected variation in community-level responses to MDA, defining a persistent hot spot obstacle to MDA success. No MDA schedule led to elimination of infection, even in those communities that started at low prevalence of infection, and it is likely that programs aiming for elimination of transmission will need to add supplemental interventions (e.g., snail control, improvement in water, sanitation and hygiene, and behavior change interventions) to achieve that next stage of control. Recommendations for future implementation research, including exploration of the value of earlier program impact assessment combined with intensification of intervention in hot spot locations, are discussed.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Bayesian Modelling and Analysis (Vounatsou)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Health Impact Assessment (Utzinger)
UniBasel Contributors:Utzinger, Jürg and Wiegand, Ryan
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:28 Jul 2020 07:53
Deposited On:28 Jul 2020 07:53

Repository Staff Only: item control page