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The rise of bio-inspired polymer compartments responding to pathology-related signals

Zartner, Luisa and Muthwill, Moritz S. and Dinu, Ionel Adrian and Schoenenberger, Cora-Ann and Palivan, Cornelia G.. (2020) The rise of bio-inspired polymer compartments responding to pathology-related signals. Journal of Materials Chemistry B, 8 (29). pp. 6252-6270 .

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Official URL: https://edoc.unibas.ch/77754/

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Abstract

Self-organized nano- and microscale polymer compartments such as polymersomes, giant unilamellar vesicles (GUVs), polyion complex vesicles (PICsomes) and layer-by-layer (LbL) capsules have increasing potential in many sensing applications. Besides modifying the physicochemical properties of the corresponding polymer building blocks, the versatility of these compartments can be markedly expanded by biomolecules that endow the nanomaterials with specific molecular and cellular functions. In this review, we focus on polymer-based compartments that preserve their structure, and highlight the key role they play in the field of medical diagnostics: first, the self-assembling abilities that result in preferred architectures are presented for a broad range of polymers. In the following, we describe different strategies for sensing disease-related signals (pH-change, reductive conditions, and presence of ions or biomolecules) by polymer compartments that exhibit stimuli-responsiveness. In particular, we distinguish between the stimulus-sensitivity contributed by the polymer itself or by additional compounds embedded in the compartments in different sensing systems. We then address necessary properties of sensing polymeric compartments, such as the enhancement of their stability and biocompatibility, or the targeting ability, that open up new perspectives for diagnostic applications.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Zartner, Luisa and Muthwill, Moritz and Dinu, Ionel Adrian and Schönenberger, Cora-Ann and Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:2050-750X
e-ISSN:2050-7518
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:11 Aug 2020 13:50
Deposited On:15 Jul 2020 07:39

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