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Human unconventional T cells in Plasmodium falciparum infection

Schmaler, Mathias and Orlova-Fink, Nina and Rutishauser, Tobias and Abdulla, Salim and Daubenberger, Claudia. (2020) Human unconventional T cells in Plasmodium falciparum infection. Seminars in immunopathology, 42 (3). pp. 265-277.

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Official URL: https://edoc.unibas.ch/77725/

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Abstract

Malaria is an old scourge of humankind and has a large negative impact on the economic development of affected communities. Recent success in malaria control and reduction of mortality seems to have stalled emphasizing that our current intervention tools need to be complemented by malaria vaccines. Different populations of unconventional T cells such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cells are gaining attention in the field of malaria immunology. Significant advances in our basic understanding of unconventional T cell biology in rodent malaria models have been made, however, their roles in humans during malaria are less clear. Unconventional T cells are abundant in skin, gut and liver tissues, and long-lasting expansions and functional alterations were observed upon malaria infection in malaria naïve and malaria pre-exposed volunteers. Here, we review the current understanding of involvement of unconventional T cells in anti-Plasmodium falciparum immunity and highlight potential future research avenues.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Clinical Immunology (Daubenberger)
UniBasel Contributors:Schmaler, Mathias and Orlova-Fink, Nina and Rutishauser, Tobias and Daubenberger, Claudia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:1863-2297
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Jul 2020 12:37
Deposited On:10 Jul 2020 12:37

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